What is the Difference Between Wegovy® and Ozempic®?

Saxenda and Semaglutide (Ozempic)

Both contain semaglutide, which is a GLP-1 analogue and are produced by Novo Nordisk pharmaceutical company based in Denmark. Ozempic® and Wegovy® are delivered as weekly injections. GLP or glucagon like peptide is a hormone produced by the intestine in response to food intake and helps in

  1. Controlling appetite
  2. Controlling blood sugar
  3. Control intestinal movement

As both medications are GLP-1 analogues, they have similar side effects and safety profile.

Ozempic®

Ozempic® contains semaglutide and is licensed for blood glucose and weight management in people with type 2 diabetes mellitus. The starting dose is 0.25mg and is gradually titrated up to 1mg.

Ozempic® is not licensed for weight loss in people who do not have type 2 diabetes.

SUSTAIN research study showed that in patients with type 2 diabetes at high cardiovascular risk, the rate of first occurrence of death from cardiovascular causes, nonfatal heart attack and stroke was significantly lower in those receiving Ozempic® compared to those patients receiving placebo.

To read more about the benefits of Ozempic®, please click this link: https://www.nejm.org/doi/full/10.1056/nejmoa1607141

Wegovy

Wegovy has been approved by FDA for chronic weight management along with life style interventions. The top dose of this weekly injection which contains semaglutide is 2.4mg.

In the STEP 1 study, participants who were overweight or obese and were given  2.4 mg of semaglutide once weekly injection in addition to lifestyle intervention had a sustained, clinically relevant reduction in body weight.

For more details on the research click this link: https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

We still do not know if Wegovy®, which is higher dose of semaglutide could be used in people with Type 2 diabetes who do respond to Ozempic® 1mg.

Please visit our site as we will be updating as and when research outcomes are released.

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Author

Dr C. Rajeswaran FRCP(UK);MSc
Consultant Physician
Obesity, Diabetes & Endocrinology

The London Obesity & Endocrine Clinic specialises in Weight Loss and Endocrine disorders at the Specialist Weight Loss Centre in Chennai, India. We offer face to face and virtual consultations with our specialist clinical lead, Dr Rajeswaran, who has 25+ years experience in this field. We support people with Obesity related medical conditions including Type 2 Diabetes, Fatty Liver, Infertility, Erectile Dysfunction, and Endocrine disorders like Hypothyroidism, Hyperthyroidism, PCOD, Hirsutism, Adrenal Dysfunction, Menopause, Pituitary problems and Sexual Dysfunction. Our services predominantly cover major cities in India including New Delhi, Bengaluru, Kolkata, Chennai, Mumbai and Pune. Many of our patients say that we are the best weight loss clinic or slimming centre in Chennai. We also offer aesthetic treatments including but not limited to: lymphatic drainage, deep tissue massage, Hydrafacial for treating skin conditions such as acne, sun damage and to help brighten the skin, CM Slim for muscle building and fat reduction, LED light therapy (including red light therapy) and much more. In addition,  we offer health checkups such as our Metabolic Master Health Checkup, diabetes health checkups, genetic testing and VO₂ Max testing for fitness and cardiorespiratory health. All of our aesthetics treatments and Bespoke Weight Management Plans are non-surgical solutions for weight loss and wellness. We have newly launched a Bespoke Wedding Weight Loss & Aesthetics Plan for brides & grooms to be. Get in touch to transform your life!

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