Polycystic Ovary Syndrome (PCOS) is a complex endocrine and metabolic disorder affecting women of reproductive age. It is characterised by hyperandrogenism, chronic anovulation, and polycystic ovarian morphology. Beyond its clinical manifestations, PCOS profoundly alters the biochemical environment of the ovary, particularly within the follicular fluid (FF), the microenvironment that supports oocyte growth and maturation. Recent advances in metabolomics, a powerful omics technology, have provided valuable insights into the molecular disturbances in FF, thereby improving our understanding of the pathophysiology of PCOS and its implications for fertility.


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